University of Nebraska–Lincoln

Welcome To AllergenOnline

AllergenOnline provides access to a peer reviewed allergen list and sequence searchable database intended for identifying proteins that may present a potential risk of allergenic cross-reactivity. This website was designed to help in assessing the safety of proteins that may be introduced into foods through genetic engineering or food processing methods.

Current Database Version 8.0

  • 1313 Peer Reviewed Sequences
  • Released: January 2008

We are Back Online!

AllergenOnline is once again "Online".

As we finalize our new hosting situation, you may find a few snags. We are still actively testing the site to make sure all is in place. If you have any concerns, questions, or simply want to point out a typo, please send us an email at
jwise@unlnotes.unl.edu.

New Feature: Allergen Groups, Group References & Group Sequences.

  • Allergen Groups: Multiple isoforms or close homologues of proteins contained in the database were clustered into related groups based on taxonomy and sequence identity. These are presented in the final column of the allergen lists viewed under the "Browse" function.
    Group names consist of the genus name, followed in some cases by IUIS, or IUIS-like designations (e.g. Arachis Ara h 1), or protein type names (e.g. Crocus profilin).

    The group name links to "Group References" describing the evidence of allergenicity for the group and a list of "Group Sequences" included in this version of the database.

Tools available:

Who We Are

Allergen Online Team

This database was developed and is maintained by the Food Allergy Research and Resource Program (FARRP) in the Department of Food Science and Technology at the University of Nebraska in Lincoln.

Peer Reviewers

A panel of scientists and clinicians are actively involved in reviewing data for inclusion of proteins in the database by comparing peer reviewed publications supporting the classification of the proteins as allergens or putative allergens following predetermined guidelines.

  • Motohiro Ebisawa, M.D.,
    National Sagamihara Hospital, Sagamihara, Japan
  • Fatima Ferreira, Ph.D.,
    University of Salzburg, Salzburg, Austria
  • Richard E. Goodman, Ph.D.,
    University of Nebraska, Lincoln, NE, USA
  • Hugh A. Sampson, M.D.,
    Mount Sinai Medical Center, New York, NY, USA
  • Steve L. Taylor, Ph.D.,
    University of Nebraska, Lincoln, NE, USA
  • Ronald van Ree, Ph.D.,
    Academic Medical Center, Amsterdam, The Netherlands
  • Stefan Vieths, Ph.D.,
    Paul-Ehrlich-Institut, Langen, Germany

Financial Support

Financial support for this database is provided by grants from corporate sponsors and FARRP (the University of Nebraska-Lincoln).

Sponsors include:

  • BASF Plant Science, LLC
  • Bayer CropScience, S.A.
  • Dow AgroSciences, LLC
  • Monsanto Company, LLC
  • Pioneer Hi-Bred International, Inc., a DuPont Company
  • Syngenta Biotechnology, Inc.

 

Bioinformatic Allergen Assessment Reports

Golden Rice 2
Report: FARRP Bioinformatic Analysis of Proteins in Golden Rice 2 to Assess Potential Allergenic Cross-Reactivity
Download: Golden Rice 2 Bioinformatics FARRP 2006.pdf

About: Golden Rice is a biofortified crop created to address the problem of vitamin A deficiency in developing countries. This was done through genetic modification of the rice plant to produce and accumulate provitamin A in the grain, a trait not found in nature. For further information on Golden Rice and the orginization that developed it, please refer to the project homepage.

Project Homepage: www.goldenrice.org